Talk to a device on 192.168.1.x via USB Ethernet when your Wi-Fi LAN is also 192.168.1.0/24 (macOS scoped route)
Give the adapter an address on that subnet as an alias and add an interface-scoped route, then bind sockets to the interface:
# no DHCP on the device side: sniff first to learn its IP/MAC
sudo tcpdump -i en9 -e -n
sudo ifconfig en9 alias 192.168.1.250/24
sudo route add -net 192.168.1.0/24 -interface en9 -ifscope en9
In Python, bind outgoing sockets to the adapter (macOS IP_BOUND_IF = 25):
import socket
s = socket.socket(socket.AF_INET, socket.SOCK_STREAM)
s.setsockopt(socket.IPPROTO_IP, 25, socket.if_nametoindex('en9'))
s.connect(('192.168.1.1', 8193))
Symptom
A machine/controller with a fixed IP (e.g. a CNC at 192.168.1.1) is connected to the Mac with a USB-Ethernet adapter (en9). The home/office Wi-Fi router is also 192.168.1.1, so traffic for 192.168.1.0/24 goes out Wi-Fi and the device is unreachable; changing Wi-Fi isn't an option.
Dead ends
route add -host 192.168.1.1 -interface en9 made ARP for the device resolve to the Mac's own MAC — don't use a -host -interface route here.
Verify
Socket bound to en9 connects to the device's port while internet over Wi-Fi keeps working.
Notes
If several devices share the same IP (e.g. identical controllers on one switch), pin each one with sudo arp -s <ip> <mac> before talking to it.
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